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KMID : 1038620120300030140
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Radiation Oncology Journal
2012 Volume.30 No. 3 p.140 ~ p.145
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Concurrent chemoradiotherapy for elderly patients with stage III non-small cell lung cancer
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Kang Ki-Mun
Jeong Bae-Kwon
Ha In-Bong
Chai Gyu-Young
Lee Gyeong-Won
Kim Hoon-Gu
Kang Jung-Hoon
Lee Won-Sup
Kang Myoung-Hee
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Abstract
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Purpose: Combined chemoradiotherapy is standard management for locally advanced non-small cell lung cancer (LA-NSCLC), but standard treatment for elderly patients with LA-NSCLC has not been confi rmed yet. We evaluated the feasibility and effi cacy of concurrent chemoradiotherapy (CCRT) for elderly patients with LA-NSCLC.
Materials and Methods: Among patients older than 65 years with LA-NSCLC, 36 patients, who underwent CCRT were retrospectively analyzed. Chemotherapy was administered 3?5 times with 4 weeks interval during radiotherapy. Thoracic radiotherapy was delivered to the primary mass and regional lymph nodes. Total dose of 54?59.4 Gy (median, 59.4 Gy) in daily 1.8 Gy fractions and 5 fractions per week.
Results: Regarding the response to treatment, complete response, partial response, and no response were shown in 16.7%, 66.7%, and 13.9%, respectively. The 1- and 2-year overall survival (OS) rates were 58.2% and 31.2%, respectively, and the median survival was 15 months. The 1- and 2-year progression-free survivals (PFS) were 41.2% and 19.5%, respectively, and the median PFS was 10 months. Regarding to the toxicity developed after CCRT, pneumonitis and esophagitis with grade 3 or higher were observed in 13.9% (5 patients) and 11.1% (4 patients), respectively. Treatment-related death was not observed.
Conclusion: The treatment-related toxicity as esophagitis and pneumonitis were noticeably lower when was compared with the previously reported results, and the survival rate was higher than radiotherapy alone. The results indicate that CCRT is an effective in terms of survival and treatment related toxicity for elderly patients over 65 years old with LA-NSCLC.
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KEYWORD
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Concurrent chemoradiotherapy, Locally advanced, Non-small-cell lung carcinoma, Old age
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